ChloroquineV1, France, Analysis, bibRecord, 000289

Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
Madagascar

Identifieur interne : 000289 ( France/Analysis ); précédent : 000288; suivant : 000290

Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
Madagascar

Source :

RBID : Hal:tel-00330591

Abstract

Our objective was to assess (i) the importance of Plasmodium vivax infections in Madagascar, (ii) the parasite sensitivity to antimalarial drugs, and (iii) molecular markers role to monitor antimalarial drug resistance.
The study was led on 8 sentinel sites. An in vivo protocol was conducted according to WHO criteria. P. vivax isolates were analysed for nucleotidic polymorphisms on pvcrt-o, pvmdr1, pvdhfr and pvdhps genes. We searched fro polymorphisms on pvcsp, pvmsp3, pvmsp1 genes and on microsatellites sequences to genotype the isolates from the in vivo protocol. Microsatellites markers were also used to assess the genetic diversity of the Malagasy isolates. Other microsatellites sequences located in the flanking regions of dhfr and dhps genes were identified to assess the origin and propagation of resistant clones.

Url:

https://tel.archives-ouvertes.fr/tel-00330591

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000162
to stream Hal, to step Curation: 000162
to stream Hal, to step Checkpoint: 000211
to stream Main, to step Merge: 001929
to stream Main, to step Curation: 001923
to stream Main, to step Exploration: 001923
to stream France, to step Extraction: 000289

Links to Exploration step

Hal:tel-00330591

Le document en format XML

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Madagascar</title>
<title xml:lang="fr">Epidemiologie moléculaire et résistance de Plasmodium vivax aux antipaludiques à Madagascar</title>
<author><name sortKey="Barnadas, Celine" sort="Barnadas, Celine" uniqKey="Barnadas C" first="Celine" last="Barnadas">Celine Barnadas</name>
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          <date type="start">2007-01-01</date>
          <date type="end">2010-12-31</date>
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          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
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          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
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            <ref type="url">https://www.universite-lyon.fr/</ref>
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<country>France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
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<title xml:lang="fr">Epidemiologie moléculaire et résistance de Plasmodium vivax aux antipaludiques à Madagascar</title>
<author><name sortKey="Barnadas, Celine" sort="Barnadas, Celine" uniqKey="Barnadas C" first="Celine" last="Barnadas">Celine Barnadas</name>
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          <date type="start">2007-01-01</date>
          <date type="end">2010-12-31</date>
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<front><div type="abstract" xml:lang="en">              <p>Our objective was to assess (i) the importance of Plasmodium vivax infections in Madagascar, (ii) the parasite sensitivity to antimalarial drugs, and (iii) molecular markers role to monitor antimalarial drug resistance.
The study was led on 8 sentinel sites. An in vivo protocol was conducted according to WHO criteria. P. vivax isolates were analysed for nucleotidic polymorphisms on pvcrt-o, pvmdr1, pvdhfr and pvdhps genes. We searched fro polymorphisms on pvcsp, pvmsp3, pvmsp1 genes and on microsatellites sequences to genotype the isolates from the in vivo protocol. Microsatellites markers were also used to assess the genetic diversity of the Malagasy isolates. Other microsatellites sequences located in the flanking regions of dhfr and dhps genes were identified to assess the origin and propagation of resistant clones.</p>
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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000289 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:tel-00330591
   |texte=   Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
Madagascar
}}

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Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs inMadagascar

Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs inMadagascar

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
Madagascar

Molecular epidemiology and resistance of Plasmodium vivax to antimalarial drugs in
Madagascar